PD30 Radioactive Seed Localization And Radio-Guided Occult Lesion Localization For Non-Palpable Breast Cancer Surgery: A Meta-Analysis

Introduction Non-palpable breast cancers require intraoperative localization to guide the surgical procedure. The radio-guided occult lesion (ROLL) and radioactive seed (RSL) techniques use material (technetium-99m labeled macroaggregated albumin iodine-125 seeds, respectively) implanted at site. success of conservative surgery depends on complete tumor excision with negative margins. objective this study was perform a meta-analysis effectiveness ROLL RSL respect rates positive margins, reoperation, recurrence. Methods A systematic search PubMed, Embase, LILACS, SciELO, Web Science databases performed 2 August 2021. standard form used extract data from studies selected in screening process. ROBINS-I tool analyze risk bias RevMan 5.4 software meta-analysis. Results Four observational met inclusion criteria. overall evidence quality moderate. included women aged 28 91 years non-palpable cancer. results demonstrated similar between for margins (risk ratio [RR] 0.83, 95% confidence interval [CI]: 0.50, 1.39; 763 patients) reoperation (RR 1.14, CI: 0.75, 1.74; 1,550 patients). Regarding rate disease recurrence, superior 0.29, 0.87; 939 Conclusions demonstrate that are equivalent although patients undergoing had lower However, there is tendency favor technique because longer implantation surgery, which possible due half-life (59.4 days). This also means can occur before neoadjuvant chemotherapy, so bed remains marked if further interventions required, obviating need another invasive procedure surgery.